Something BIG is happening! Harvard and MIT team demonstrated reprogramming of mouse fibroblasts to a pluripotent state in vitro through ectopic expression of the four transcription factors (or pluripotency genes), named Oct4 (also called Oct3/4 or Pou5f1), Sox2, c-Myc and Klf4. And the outcome is.....
Yes! Mouse fibroblasts 'can' form viable chimaeras, and can be reprogrammed to behave like a totipotent zygote to form all three germ layers and subsequent entire clone using somatic cell nuclear transfer technology.
Read more about this interesting article at Nature.com
Picture copyrighted by: Marius Wernig, Alexander Meissner, Ruth Foreman, Tobias Brambrink, Manching Ku, Konrad Hochedlinger, Bradley E. Bernstein, Rudolf Jaenisch | In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state | Nature advance online publication 6 June 2007 | doi:10.1038/nature05944
Related posts:
1. Reprogramming the Cell | Part 1: Basics of Stem Cell
2. Reprogramming the Cell | Part 2: Road to a unipotent adult cell (Programming Cell)
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